Seven DNA clues hint at a biological cause for chronic fatigue syndrometest

Seven spots in human DNA may raise the risk of ME/CFS, a long illness of exhaustion that rest does not fix. Researchers scanned the DNA of 1,268 patients, then re-checked those spots in two smaller patient groups.test

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Why it matters

Millions of people live with this illness, whose full name is myalgic encephalomyelitis, or chronic fatigue syndrome. There is still no test for it and no treatment, and many patients are told their tiredness is not real. Finding DNA spots tied to the illness supports the idea that something physical is going on in the body, and several of the spots sit near genes active in the brain. These are early clues, though: only seven of 176 first signals showed up again, and none were strong in all three groups of patients.test

Who's behind it: J. Slaughter, C. P. Ponting and colleagues, University of Edinburgh.

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